Detection and Decontamination of Chronic Wasting Disease Prions during Venison Processing

Detection and Decontamination of Chronic Wasting Disease Prions during Venison Processing

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Prion diseases, including chronic wasting disease (CWD), are caused by prions, which are misfolded aggregates of normal cellular prion protein.Prions possess many characteristics that distinguish them from conventional pathogens, in particular, an extraordinary cashel tail bag recalcitrance to inactivation and a propensity to avidly bind to surfaces.In middle to late stages of CWD, prions begin accumulating in cervid muscle tissues.Those features collectively create scenarios in which occupational hazards arise for workers processing venison and pose risks to consumers through direct prion exposure through ingestion and cross-contamination of food products.In this study, we demonstrate that steel and plastic surfaces used in venison processing can be directly contaminated with CWD prions and that cross-contamination of CWD-negative venison can occur from equipment that had vlone stop snitching shirt previously been used with CWD-positive venison.

We also show that several decontaminant solutions (commercial bleach and potassium peroxymonosulfate) are efficacious for prion inactivation on those same surfaces.